abstract：:Hypertension and related oxidative stress are involved in the pathogenesis of any renal diseases. Angiotensin-converting enzyme inhibitors have multi-directional renoprotective effects. In this study, we aimed to investigate whether lisinopril treatment has any biochemical alterations on renal tissue in L-NAME (Nε-nit...

journal_title：Molecular and cellular biochemistry

authors： Oktem F,Kirbas A,Armagan A,Kuybulu AE,Yilmaz HR,Ozguner F,Uz E

更新日期：2011-06-01 00:00:00

abstract：:microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by targeting mRNAs, inhibiting the expression of the associated proteins. Although a role for aberrant miRNA expression in cancer has been postulated, the pathophysiologic role and relevance of aberrantly expressed miRNAs in tumor biology has n...

journal_title：Molecular and cellular biochemistry

authors： Wang C,Bian Z,Wei D,Zhang JG

更新日期：2011-06-01 00:00:00

abstract：:Mucus hypersecretion is an important manifestation in patients with chronic inflammatory airway diseases. Mucin 5AC (MUC5AC) is a major component of airway mucus. MUC5AC expression is regulated by epidermal growth factor receptor (EGFR) which can be activated by reactive oxygen species (ROS). Hyaluronan (HA), a linear...

journal_title：Molecular and cellular biochemistry

authors： Yu H,Li Q,Zhou X,Kolosov VP,Perelman JM

更新日期：2011-06-01 00:00:00

abstract：:Heat shock factor 1 (HSF1) is the major heat shock transcription factor and plays an essential role in mediating the cellular response to physiological and environmental stress. We found that LPS-induced expression of the granulocyte-colony stimulating factor (G-CSF) gene was upregulated in HSF1 knock-out (HSF1(-/-)) ...

journal_title：Molecular and cellular biochemistry

authors： Zhang L,Yang M,Wang Q,Liu M,Liang Q,Zhang H,Xiao X

更新日期：2011-06-01 00:00:00

abstract：:Diabetes is associated with increased oxidative stress and impaired antioxidant defenses. Thioredoxin-1 (TRX-1) is a cytosolic thiol antioxidant and redox-active protein which plays a vital role in the maintenance of reduced intracellular redox state. In this study, the authors examined whether 4-week treatments with ...

journal_title：Molecular and cellular biochemistry

authors： Atalay M,Bilginoglu A,Kokkola T,Oksala N,Turan B

更新日期：2011-05-01 00:00:00

abstract：:Proteoglycans carrying chondroitin sulfate side chains have been shown to fulfill important biological functions in development, disease, and signaling. One area of considerable interest is the functional importance of chondroitin sulfates as inhibitors of the regeneration of axonal projections in the mammalian centra...

journal_title：Molecular and cellular biochemistry

authors： Klüppel M

更新日期：2011-05-01 00:00:00

abstract：:A quarter of the human population with European background carries at least one allele of the OPRD1 gene that encodes the delta opioid receptor with cysteine at the amino acid position 27 (hδOR(Cys27)) instead of the evolutionary conserved phenylalanine (hδOR(Phe27)). The two variants have indistinguishable pharmacolo...

journal_title：Molecular and cellular biochemistry

authors： Tuusa JT,Petäjä-Repo UE

更新日期：2011-05-01 00:00:00

abstract：:The aim of this study was to screen for differential expression of signaling pathways in odontogenic differentiation of ectomesenchymal cells isolated from the first branchial arch of embryonic day 10 (E10) mice by real time RT-PCR microarray. Observations of cellular morphology, immunocytochemistry, and RT-PCR were u...

journal_title：Molecular and cellular biochemistry

authors： Yu Y,Li M,Sun J,Yang M,Long J,Tian W,Tang W,Li T,Liu L

更新日期：2011-05-01 00:00:00

abstract：:MicroRNAs have been implicated in regulating diverse cellular pathways. Emerging evidence indicates that miR-143 plays causal roles in cancer tumorigenesis as a tumor suppress gene; however, its role in prostate cancer tumorigenesis remains largely unknown. The aims of this study were to verify the effect of miR-143 o...

journal_title：Molecular and cellular biochemistry

authors： Xu B,Niu X,Zhang X,Tao J,Wu D,Wang Z,Li P,Zhang W,Wu H,Feng N,Wang Z,Hua L,Wang X

更新日期：2011-04-01 00:00:00

abstract：:We investigated the expression of the nuclear-encoded genes controlling the mitochondrial properties in the mouse gastrocnemius muscle to gain insight into the mitochondrial biogenesis that occurs during the muscle degeneration/regeneration induced by freezing. In addition, we tested whether the muscle regeneration is...

journal_title：Molecular and cellular biochemistry

authors： Wagatsuma A,Kotake N,Yamada S

更新日期：2011-03-01 00:00:00

abstract：:Caffeic acid (3,4-dihydroxy cinnamic acid) (CA) is naturally found in fruits, vegetables, olive oil, and coffee. This study was undertaken to evaluate the anticancer effect of caffeic acid on HT-1080 human fibrosarcoma cell line. The antiproliferative effect of caffeic acid was determined by MTT assay, and the oxidati...

journal_title：Molecular and cellular biochemistry

authors： Rajendra Prasad N,Karthikeyan A,Karthikeyan S,Reddy BV

更新日期：2011-03-01 00:00:00

abstract：:Under synchronized conditions daily rhythms run in precise phase relationships. Long lasting shift-work disturbs circadian rhythms and causes metabolism dysfunction. As a result of frequent shifts of the light (L):dark (D) cycle the circadian system has to adjust to a new regimen repeatedly, and organism can never ach...

journal_title：Molecular and cellular biochemistry

authors： Szántóová K,Zeman M,Veselá A,Herichová I

更新日期：2011-02-01 00:00:00

abstract：:To explore the effect of LYRM1 over-expression on basal and insulin-stimulated glucose uptake in rat skeletal muscle cells, and to understand the underlying mechanisms, Rat myoblasts (L6) transfected with either an empty expression vector (pcDNA3.1Myc/His B) or a LYRM1 expression vector were differentiated into myotub...

journal_title：Molecular and cellular biochemistry

authors： Kou C,Cao X,Qin D,Ji C,Zhu J,Zhang C,Zhu C,Gao C,Chen R,Guo X,Zhang M

更新日期：2011-02-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) has been thought to play a major role during cardiac fibrosis in the development of diabetic cardiomyopathy, and cardiac fibrosis mainly as a result of an increase of collagen type III occurs in the human hearts with diabetes. Thrombospondin-1 (TSP-1) has been reported to activat...

journal_title：Molecular and cellular biochemistry

authors： Tang M,Zhou F,Zhang W,Guo Z,Shang Y,Lu H,Lu R,Zhang Y,Chen Y,Zhong M

更新日期：2011-01-01 00:00:00

abstract：:Airways inflammation, a pathological hallmark of asthma, is associated with the recruitment of pro-inflammatory and inflammatory cells like eosinophils, polymorphonuclear leucocytes cells, mononuclear cells, macrophages, epithelial desquamation, and airways remodeling with sub-epithelial fibrosis. Activated inflammato...

journal_title：Molecular and cellular biochemistry

authors： Khanduja KL,Kaushik G,Khanduja S,Pathak CM,Laldinpuii J,Behera D

更新日期：2011-01-01 00:00:00

abstract：:The ubiquitin specific peptidase 22 (USP22) is a positive regulator of the growth of tumors. However, little is known about the impact of USP22 knockdown on the growth of human bladder cells. In the present study, we designed a series of asymmetric interfering RNAs (aiRNAs) and compared the efficacy of aiRNA and conve...

journal_title：Molecular and cellular biochemistry

authors： Lv L,Xiao XY,Gu ZH,Zeng FQ,Huang LQ,Jiang GS

更新日期：2011-01-01 00:00:00

abstract：:Diabetes mellitus is a serious global health problem, and cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. The chronic effects of neonatal alloxan- (ALX) induced diabetes mellitus on ventricular myocyte contraction and intracellular Ca(2+) transport have been investigat...

journal_title：Molecular and cellular biochemistry

authors： Howarth FC,Hassan Z,Qureshi MA

更新日期：2011-01-01 00:00:00

abstract：:Huge data accumulated in last few years have shown that differential expression of candidate miRNAs in normal versus transformed cell provides important insights into the pathogenesis of cancer including leukemias. In our previous report, we have revealed that miR-196b was significantly down-regulated in both EB-3 cel...

journal_title：Molecular and cellular biochemistry

authors： Bhatia S,Kaul D,Varma N

更新日期：2011-01-01 00:00:00

abstract：:The development of hypercholesterolemia is a multifactorial process in which elevated plasma cholesterol levels play a central role. This study analyzed the variability of the expression and activity of myosin light chain kinase (MLCK) and endothelial permeability in the artery wall of rabbits after feeding the animal...

journal_title：Molecular and cellular biochemistry

authors： Zhu HQ,Zhou Q,Jiang ZK,Gui SY,Wang Y

更新日期：2011-01-01 00:00:00

abstract：:The monoterpene perillyl alcohol (POH) is a drug used in the treatment of several malignant tumors, including gliomas. The present study defines a POH inhibitory effect on Na/K-ATPase activity from kidney and brain guinea pig extracts and from a human glioblastoma cell line. This inhibition showed a high degree of sel...

journal_title：Molecular and cellular biochemistry

authors： Garcia DG,Amorim LM,de Castro Faria MV,Freire AS,Santelli RE,Da Fonseca CO,Quirico-Santos T,Burth P

更新日期：2010-12-01 00:00:00

abstract：:A systematic comparison of the impact of some potential endocrine disruptors (EDs) on modulation of androgen receptor (AR) and pregnane and xenobiotic receptor (PXR) function was conducted in a multi-step analysis. Promoter-reporter-based transcription assays were performed in conjunction with receptor dynamic studies...

journal_title：Molecular and cellular biochemistry

authors： Chaturvedi NK,Kumar S,Negi S,Tyagi RK

更新日期：2010-12-01 00:00:00

abstract：:Activation of either the A(1) adenosine receptor (A(1)R) or the A(3) adenosine receptor (A(3)R), by their specific agonists CCPA and Cl-IB-MECA, respectively, protects cardiac cells in culture against ischemic injury. Yet the full protective mechanism remains unclear. In this study, we therefore examined the involveme...

journal_title：Molecular and cellular biochemistry

authors： Leshem-Lev D,Hochhauser E,Chanyshev B,Isak A,Shainberg A

更新日期：2010-12-01 00:00:00

abstract：:Ischemia/reperfusion injury causes cardiomyocyte apoptosis, ventricular remodeling, leading to a dilated heart. Hypoxia is one of the causes involved in ischemia damage, and BNIP3 is a hypoxia-inducible marker and also a sensor to induce mitochondria-dependent apoptosis. Recent reports discussed ablating BNIP3 can res...

journal_title：Molecular and cellular biochemistry

authors： Weng YJ,Kuo WW,Kuo CH,Tung KC,Tsai CH,Lin JA,Tsai FJ,Hsieh DJ,Huang CY,Hwang JM

更新日期：2010-12-01 00:00:00

abstract：:Skp2 is frequent amplified and overexpressed in breast cancer, making it a potential molecular target for cancer therapy. The objective of this study was to examine the effect of PPARγ overexpression on Skp2 expression in breast cancer cell lines. First, we investigated the role of PPARγ and Skp2 in human breast cance...

journal_title：Molecular and cellular biochemistry

authors： Meng J,Ding Y,Shen A,Yan M,He F,Ji H,Zou L,Liu Y,Wang Y,Lu X,Wang H

更新日期：2010-12-01 00:00:00

abstract：:Progression of prostate cancer is facilitated by growth factors that activate critical signaling cascades thereby promote prostate cancer cell growth, survival, and migration. To investigate the effect of quercetin on insulin-like growth factor signaling and apoptosis in androgen independent prostate cancer cells (PC-...

journal_title：Molecular and cellular biochemistry

authors： Senthilkumar K,Elumalai P,Arunkumar R,Banudevi S,Gunadharini ND,Sharmila G,Selvakumar K,Arunakaran J

更新日期：2010-11-01 00:00:00

abstract：:Liver regeneration is an angiogenesis-associated phenomenon. To identify key plasma membrane (PM) proteins of endothelial cells involved in the initiation of angiogenesis during liver regeneration, the PM of liver sinusoidal endothelial cells (LSEC) at 72 h after partial hepatectomy was enriched by an established in v...

journal_title：Molecular and cellular biochemistry

authors： Li X,Xiong L,Xie C,Cao J,Deng H,Lin Y,Cao R,Li J,Chen P,Liang S

更新日期：2010-11-01 00:00:00

abstract：:Fibrates and WY-14643 are widely used as lipid-lowering drugs via modulation of peroxisome proliferator-activated receptor alpha (PPAR α) for the treatment of a wide range of metabolic disorders. Here, to address the question whether PPAR α agonists can affect the enzymatic activity of 11beta-hydroxysteroid dehydrogen...

journal_title：Molecular and cellular biochemistry

authors： Kim CH,Ramu R,Ahn JH,Bae MA,Cho YS

更新日期：2010-11-01 00:00:00

abstract：:Plexiform neurofibromas commonly found in patients with Neurofibromatosis type I (NF1) have a 5% risk of being transformed into malignant peripheral nerve sheath tumors (MPNST). Germline mutations in the NF1 gene coding for neurofibromin, which is a Ras GTPase activating protein (RasGAP) and a negative regulator of Ra...

journal_title：Molecular and cellular biochemistry

authors： Kraniak JM,Sun D,Mattingly RR,Reiners JJ Jr,Tainsky MA

更新日期：2010-11-01 00:00:00

abstract：:Adipose tissue is a major reservoir of cholesterol and, as such, it may play a significant role in cholesterol homeostasis. The aims of this study were to obtain a quantitative characterization of apolipoprotein A-I (apoA-I)-dependent lipid efflux from adipocytes and examine the role of ATP-binding cassette transporte...

journal_title：Molecular and cellular biochemistry

authors： Howard AD,Verghese PB,Arrese EL,Soulages JL

更新日期：2010-10-01 00:00:00

abstract：:Histone acetylation and deacetylaion play important roles in chromatin remodeling and gene expression. An imbalance of these reactions leads to aberrant behavior of the cells in the cell cycle, which in turn contributes to carcinogenesis. Histone deacetylase (HDAC) inhibitors have been shown to have anti-tumor effects...

journal_title：Molecular and cellular biochemistry

authors： Lee KH,Choi EY,Kim MK,Kim KO,Jang BI,Kim SW,Kim SW,Song SK,Kim JR

更新日期：2010-10-01 00:00:00

abstract：:DNA methylation plays an important role in regulation of gene expression and is increasingly being recognized as a determinant of chemosensitivity of human cancers. With the aim of improving the chemotherapeutic efficacy of breast carcinoma, the effect of DNA methyltransferase inhibitor, 5-Aza-2'-deoxycytidine (5-aza-...

journal_title：Molecular and cellular biochemistry

authors： Mirza S,Sharma G,Pandya P,Ralhan R

更新日期：2010-09-01 00:00:00

abstract：:Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17beta-estradiol treatment is sufficient to inhibit prostaglandin E2 (PGE2)-induced cellular motility in human colon cancer cells. Upregulation of cyclooxygenase-2 (...

journal_title：Molecular and cellular biochemistry

authors： Lai TY,Chen LM,Lin JY,Tzang BS,Lin JA,Tsai CH,Lin YM,Huang CY,Liu CJ,Hsu HH

更新日期：2010-09-01 00:00:00

abstract：:The angiotensin converting enzyme (ACE) is a key factor in the production of angiotensin II and in the degradation of bradykinin. Chronic exposure to high levels of circulating and tissue ACE predispose to vascular wall thickening and atherosclerosis. Factor VII (FACTOR VII) is the first enzyme in the extrinsic pathwa...

journal_title：Molecular and cellular biochemistry

authors： Sobti RC,Maithil N,Thakur H,Sharma Y,Talwar KK

更新日期：2010-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of non-coding small RNAs. They play an important role as a post-transcriptional regulator in the protein synthesis and are involved in cellular processes, such as proliferation, apoptosis, and differentiation. miRNAs give us a new perspective to understand carcinogenesis. Since the high-...

journal_title：Molecular and cellular biochemistry

authors： Xie L,Qian X,Liu B

更新日期：2010-08-01 00:00:00

abstract：:Gastric pathology is a common complication in diabetes mellitus. The aim of the study was to evaluate the functions and morphological changes of the parietal cells of the rat stomach after streptozotocin-induced diabetes. Diabetes mellitus was induced in Wistar rats by a single intraperitoneal injection of streptozoto...

journal_title：Molecular and cellular biochemistry

authors： Bastaki SM,Adeghate E,Chandranath IS,Amir N,Tariq S,Hameed RS,Adem A

更新日期：2010-08-01 00:00:00

abstract：:Bipolar disorder (BD) is a psychiatric disorder characterized by alternating episodes of mania and depression. The intracerebroventricular (i.c.v) administration of ouabain (a Na(+)/K(+)-ATPase inhibitor) in rats has been used as an animal model of mania, because present face, construct and predictive validities. Seve...

journal_title：Molecular and cellular biochemistry

authors： Freitas TP,Rezin GT,Gonçalves CL,Jeremias GC,Gomes LM,Scaini G,Teodorak BP,Valvassori SS,Quevedo J,Streck EL

更新日期：2010-08-01 00:00:00

abstract：:Lysosomes are a cell organelle type processing antimicrobial activity. Here, we investigate the lysosomal activity in a primary cell line, bovine aortic endothelial cells (BAECs), during cellular aging, based on the antimicrobial activity of lysosomes isolated from BAECs at cell passages 4, 6, 8, and 10. Cytochemical ...

journal_title：Molecular and cellular biochemistry

authors： Yoon J,Kim KJ,Choi YW,Shin HS,Kim YH,Min J

更新日期：2010-07-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase which participates in many important cellular processes such as cell adhesion and migration. However, the role of FAK in renal tubular epithelial-to-mesenchymal transition (EMT) is still unknown. FAK was knocked down by transfection of specific small interf...

journal_title：Molecular and cellular biochemistry

authors： Deng B,Yang X,Liu J,He F,Zhu Z,Zhang C

更新日期：2010-07-01 00:00:00

abstract：:The underlying molecular mechanism of carcinogenesis in oral squamous cell carcinoma (OSCC) is poorly understood and appears to be controlled on many genetic, environmental, and hormonal factors. Obestatin and ghrelin, two recently discovered hormones, are co-expressed in endocrine cells. The purpose of this investiga...

journal_title：Molecular and cellular biochemistry

authors： Alnema MM,Aydin S,Ozkan Y,Dagli AF,Ozercan HI,Yildirim N,Sahin I,Karaoglu A,Kilic N,Yilmaz M,Ozercan MR,Donder E

更新日期：2010-06-01 00:00:00

abstract：:Free fatty acids (FFA)-induced proliferation and apoptosis was studied in human umbilical vein endothelial cells (HUVECs). A recombinant adenovirus containing a RNAi cassette targeting the GSK-3beta gene was produced and its silencing effect on GSK-3beta gene was detected by Western blot analysis and immunohistochemis...

journal_title：Molecular and cellular biochemistry

authors： Zhu P,Chen G,You T,Yao J,Jiang Q,Lin X,Shen X,Qiao Y,Lin L

更新日期：2010-05-01 00:00:00